Welcome

Welcome to the website of the Green lab in the Biomedical Engineering Department at Boston University.

Research

Our group pursues highly interdisciplinary research at the interfaces of chemistry, biology, and materials science. Much of this work exploits programmable molecular interactions between nucleic acids and proteins to direct the assembly of nanometer-scale organic and inorganic components and to construct information-processing circuitry inside living cells. These efforts have wide-ranging implications for biotechnology, medicine, biosensing, and nanotechnology.

 

News

The latest news and developments from the Green lab at BU.

SNIPRs take aim at disease-related mutations

Researchers from the Green lab at Arizona State University have reported a highly specific method for detecting point mutations. The technique can be applied in living cells and paper-based diagnostic tests, offering a rapid, highly accurate and inexpensive means of identifying mutations relevant to human health. The work is published in Cell. (ASU Biodesign story)

Mahmoud Matar Abed: Master’s Defense

Mahmoud successfully defended his Master’s thesis on artificial enzymes based on two-dimensional nanomaterials. Congratulations!

Duo Ma: PhD Defense

Lab member Duo Ma successfully defended his PhD dissertation entitled “RNA-Based Computing Devices for Intracellular and Diagnostic Applications”. Congratulations, Duo!

Lab Members

Prof. Alexander A. Green

Alexander Green is an Assistant Professor in the Biomedical Engineering Department at Boston University. (More…)

Kirstie Swingle

Kirstie graduated from University of New Mexico with a B.S. in biology in 2014. She joined School of Molecular Sciences at ASU in 2016. Her research focuses on DNA/antibody systems for diagnostic design. In her free time, Kirstie likes reading, dancing, music, and hanging out outdoors. 

Soma Chaudhary

Soma joined School of Molecular Sciences in 2016. She obtained BS-MS dual degree from Indian Institute of Science Education and Research, Thiruvananthapuram (IISER-TVM) majoring in Chemistry. Her research focuses on reengineering nonribosomal peptide synthesis and developing novel diagnostic methods. In her spare time, she likes travel, cooking, and watching TV series. 

Griffin McCutcheon

Griffin graduated in 2014 from Johns Hopkins University in Chemical and Biomolecular Engineering. Following work at the NASA Ames Research Center, Griffin joined the the Biological Design PhD program in 2017. His research is focused on RNA-based circuits and genetic encoding of novel materials and structures. Outside of the lab, Griffin enjoys cooking, home improvement, and woodworking, as well as mountain biking.

Zhaoqing Yan

Zhaoqing joined as Ph.D. student in 2017 and is in the BU MCBB program. He completed his B.Sc. degree in chemistry at the University of Jinan in 2016. He is interested in the programming DNA and RNA molecules that can be used for reporting or recording dynamic biological events. In his spare time, he enjoys playing badminton, dubbing, and playing flute.

Zachary Ticktin

Zach is a 4+1 student completing his masters in Biomedical Engineering. He is interested in designing biological circuits to detect infectious diseases and modulate gene expression. Outside of the lab he enjoys golfing and working as a medical scribe in the Banner Thunderbird Emergency department. 

Publications

Google Scholar
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* denotes equal contribution

  1. Q. Zhang, D. Ma, F. Wu, K. Standage-Beier, X. Chen, K. Wu, A. A. Green & X. Wang, “Predictable control of RNA lifetime using engineered degradation-tuning RNAs,” Nature Chemical Biology 17, 828–836 (2021).
    [ Journal ]

  2. A. Yousaf, M. S. Gilliam, S. L. Y. Chang, M. Augustin, Y. Guo, F. Tahir, M. Wang, A. Schwindt, X. S. Chu, D. O. Li, S. Kale, A. Debnath, Y. Liu, M. D. Green, E. J. G. Santos, A. A. Green & Q. H. Wang, “Exfoliation of Quasi-Two-Dimensional Nanosheets of Metal Diborides,” Journal of Physical Chemistry C 125 (12), 6787–6799 (2021).
    [ Journal ]

  3. A. Debnath, S. Saha, D. O. Li, X. S. Chu, Z. W. Ulissi, A. A. Green† & Qing Hua Wang, “Elimination of Multidrug-Resistant Bacteria by Transition Metal Dichalcogenides Encapsulated by Synthetic Single-Stranded DNA,” ACS Applied Materials & Interfaces 13 (7), 8082–8094 (2021).
    [ Journal ]

  4. E. Amalfitano*, M. Karlikow*, M. Norouzi*, K. Jaenes, S. Cicek, F. Masum, P. Sadat Mousavi, Y. Guo, L. Tang, A. Sydor, Duo Ma, J. D. Pearson, D. Trcka, M. Pinette, A. Ambagala, S. Babiuk, B. Pickering, J. Wrana, R. Bremner, T. Mazzulli, D. Sinton, J. H. Brumell, A. A. Green & K. Pardee, “A glucose meter interface for point-of-care gene circuit-based diagnostics,” Nature Communications 12, 724 (2021).
    [ Journal ]

  5. M. S. Gilliam*, A. Yousaf*, Y. Guo, D. O. Li, A. Momenah, Q. H. Wang & A. A. Green, “Evaluating the Exfoliation Efficiency of Quasi-2D Metal Diboride Nanosheets Using Hansen Solubility Parameters,” Langmuir 37 (3), 1194–1205 (2021).
    [ Journal ]

  6. Y. Guo, A. Gupta, M. S. Gilliam, A. Debnath, A. Yousaf, S. Saha, M. D. Levin, A. A. Green, A. K. Singh & Q. H. Wang, “Exfoliation of boron carbide into ultrathin nanosheets,” Nanoscale 13, 1652-1662 (2021).
    [ Journal ]

  7. D. O. Li, M. S. Gilliam, A. Debnath, X. S. Chu, A. Yousaf, A. A. Green & Q. H. Wang, “Interaction of Pb2+ ions in water with two-dimensional molybdenum disulfide,” Journal of Physics: Materials 3, 024007 (2020).
    [ Journal ]

  8. F. Hong, D. Ma, K. Wu, L. A. Mina, R. C. Luiten, Y. Liu, H. Yan & A. A. Green, “Precise and Programmable Detection of Mutations Using Ultraspecific Riboregulators,” Cell 180, 1018-1032 (2020).
    [ Journal | PDF | SNIPR design code ]

  9. P. Sadat Mousavi*, S. J. Smith*, J. B. Chen*, M. Karlikow, A. Tinafar, C. Robinson, W. Liu, D. Ma, A. A. Green, S. O. Kelley & K. Pardee, “A multiplexed, electrochemical interface for gene-circuit-based sensors,” Nature Chemistry 12, 48–55 (2020).
    [ Journal ]

  10. J. Kim*, Y. Zhou*, P. Carlson, M. Teichmann, S. Chaudhary, F. C. Simmel, P. A. Silver, J. J. Collins, J. B. Lucks, P. Yin & A. A. Green, “De-Novo-Designed Translation-Repressing Riboregulators for Multi-Input Cellular Logic,” Nature Chemical Biology 15, 1173–1182 (2019).
    [ JournalbioRxiv | Sequence tables ]

Funding

We gratefully acknowledge these funding agencies and foundations for their ongoing and past support of our work.