Welcome

Welcome to the website of the Green lab in the Biomedical Engineering Department at Boston University.

Green lab group photo May 2022

Research

Our group pursues highly interdisciplinary research at the interfaces of chemistry, biology, and materials science. Much of this work exploits programmable molecular interactions between nucleic acids and proteins to direct the assembly of nanometer-scale organic and inorganic components and to construct information-processing circuitry inside living cells. These efforts have wide-ranging implications for biotechnology, medicine, biosensing, and nanotechnology.

 

News

The latest news and developments from the Green lab at BU.

SNIPRs take aim at disease-related mutations

Researchers from the Green lab at Arizona State University have reported a highly specific method for detecting point mutations. The technique can be applied in living cells and paper-based diagnostic tests, offering a rapid, highly accurate and inexpensive means of identifying mutations relevant to human health. The work is published in Cell. (ASU Biodesign story)

Mahmoud Matar Abed: Master’s Defense

Mahmoud successfully defended his Master’s thesis on artificial enzymes based on two-dimensional nanomaterials. Congratulations!

Duo Ma: PhD Defense

Lab member Duo Ma successfully defended his PhD dissertation entitled “RNA-Based Computing Devices for Intracellular and Diagnostic Applications”. Congratulations, Duo!

Lab Members

Prof. Alexander A. Green

Alexander Green is an Assistant Professor in the Biomedical Engineering Department at Boston University. (More…)

Milad Babaei

Milad graduated in 2018 from BU where he obtained his Bachelors in Biochemistry and Molecular Biology and Masters in Biotechnology. His research focus entails development of DNA nanodevices that can simultaneously amplify nucleic acid targets while providing fast readout. In his spare time, he enjoys jogging and exploring designs in silico.

Jiayi Li

Jiayi grew up in China and graduated from UC San Diego with a B.S. degree in Bioengineering: Biotechnology. She joined the Ph.D. program in Biomedical Engineering at BU in 2020. She is interested in engineering RNA-based circuits for imaging and biosensing. In her free time, she enjoys listening to music and reading fantasy novels.

James Robson

James earned his bachelor’s degree in biomedical engineering from Boston University in 2020 and joined the Ph.D. program in the same year. As an SB2 trainee, he is interested in engineering biological systems by designing RNA and DNA structures to modulate gene expression. Outside of the lab, he enjoys playing in local orchestras, chamber ensembles, and wind ensembles, as well as baking, watching movies, and volunteering.

Rebecca Kang

Rebecca is from Singapore. She graduated from Carnegie Mellon University with a B.S. in Chemical and Biomedical Engineering and joined the BU BME Ph.D. program in 2019. Her research focuses on nucleic acid design for synthetic biology in cell-free systems and mammalian cells. Outside of the lab, Rebecca is part of a loving spiritual family at Symphony Church. She enjoys boxing and trying out new restaurants.

Dayna Francis

Dayna is a senior studying biochemistry and molecular biology. She is gaining experience in synthetic biology and learning about RNA circuits to further medicine. In her free time, she loves to experiment with hairstyles/hair colors, cook, and spend time with friends and family.

Publications

Google Scholar
denotes corresponding author
* denotes equal contribution

  1. K. Wu & A. A. Green, “Sensitive detection of SARS-CoV-2 on paper,” Nature Biomedical Engineering 6, 928-929 (2022).
    [ Journal ]

  2. K. Jaenes*, S. J. Ribeiro da Silva*, J. R. J. Vigar*, K. Wu, M. Norouzi, P. Bayat, M. Karlikow, S. Cicek, Y. Guo, A. A. Green, L. Pena & K. Pardee, “Design to Implementation Study for Development and Patient Validation of Paper-Based Toehold Switch Diagnostics,” JoVE 184, e63223 (2022).
    [ Journal | PDF ]

  3. J. M. Robson & A. A. Green, “Closing the loop on crowdsourced science,” Proc. Natl. Acad. Sci. U.S.A. 119, e2205897119 (2022).
    [ Journal ]

  4. A. A. Green, “Enzyme assemblies on demand,” Nature Chemical Biology 18, 436–438 (2022).
    [ Journal ]

  5. D. Ma, Y. Li, K. Wu, Z. Yan, A. A. Tang, S. Chaudhary, Z. M. Ticktin, J. Alcantar-Fernandez, J. L. Moreno-Camacho, A. Campos-Romero & A. A. Green, “Multi-arm RNA junctions encoding molecular logic unconstrained by input sequence for versatile cell-free diagnostics,” Nature Biomedical Engineering 6, 298–309 (2022).
    [ Journal | PDF ]

  6. M. Karlikow*, S. J. R. da Silva*, Y. Guo*, S. Cicek*, L. Krokovsky*, P. Homme, Y. Xiong, T. Xu, M.-A. Calderón-Peláez, S. Camacho-Ortega, D. Ma, J. J. F. de Magalhães, B. N. R. R. Souza, D. G. de Albuquerque Cabral, K. Jaenes, P. Sutyrina, T. Ferrante, A. D. Benitez, V. Nipaz, P. Ponce, D. G. Rackus, J. J. Collins, M. Paiva, J. E. Castellanos, V. Cevallos, A. A. Green, C. Ayres, L. Pena & K. Pardee, “Field validation of the performance of paper-based tests for the detection of the Zika and chikungunya viruses in serum samples,” Nature Biomedical Engineering 6, 246–256 (2022).
    [ Journal | PDF ]

  7. A. R. Carr, J. L. Dopp, K. Wu, P. Sadat Mousavi, Y. R. Jo, C. E. McNeley, Z. T. Lynch, K. Pardee, A. A. Green & N. F. Reuel, “Toward Mail-in-Sensors for SARS-CoV-2 Detection: Interfacing Gel Switch Resonators with Cell-Free Toehold Switches,” ACS Sensors 7, 806–815 (2022).
    [ Journal ]

  8. S. Saha, M. S. Gilliam, Q. H. Wang† & Alexander A. Green, “Eradication of Fungi Using MoSe2/Chitosan Nanosheets,” ACS Applied Nano Materials 5, 133-148 (2022).
    [ Journal ]

  9. Q. Zhang, D. Ma, F. Wu, K. Standage-Beier, X. Chen, K. Wu, A. A. Green & X. Wang, “Predictable control of RNA lifetime using engineered degradation-tuning RNAs,” Nature Chemical Biology 17, 828–836 (2021).
    [ Journal ]

  10. A. Yousaf, M. S. Gilliam, S. L. Y. Chang, M. Augustin, Y. Guo, F. Tahir, M. Wang, A. Schwindt, X. S. Chu, D. O. Li, S. Kale, A. Debnath, Y. Liu, M. D. Green, E. J. G. Santos, A. A. Green & Q. H. Wang, “Exfoliation of Quasi-Two-Dimensional Nanosheets of Metal Diborides,” Journal of Physical Chemistry C 125 (12), 6787–6799 (2021).
    [ Journal ]

Openings

We have open positions at Boston University of graduate students and postdoctoral fellows.

Postdoctoral Positions Available for Rapid Multi-Modal Diagnostics Development